Ankylosing Spondylitis Disease Activity Score with ESR (ASDAS-ESR)

The ASDAS‑ESR is a composite index that quantifies axial spondyloarthritis activity by combining patient‑reported symptoms with the erythrocyte sedimentation rate.

Back pain
001+12+23+34+45+56+67+78+89+910+10
Duration of morning stiffness
001+12+23+34+45+56+67+78+89+910+10
Patient global assessment of disease activity
001+12+23+34+45+56+67+78+89+910+10
Peripheral pain/swelling
001+12+23+34+45+56+67+78+89+910+10
mm/hr

适用指征

Used to quantify disease activity in axial spondyloarthritis, guide treatment escalation, and classify inactive, low, high, or very high disease activity based on validated cut‑offs (≤1.3, >1.3–2.1, >2.1–3.5, >3.5) 1 [Level I evidence]. Clinically useful for routine monitoring every 3–4 months, as it correlates with radiographic progression 2 [Level II evidence] and reflects both patient symptoms and inflammation more accurately than BASDAI 3 [Level II evidence].

洞见与注意事项

Reflects combined symptoms and ESR to classify activity and track response, correlating well with patient/physician assessments and outperforming BASDAI in discrimination 1 [Level II evidence].
Usefulness includes validated cut‑offs and strong links to MRI and radiographic progression 2 [Level II evidence].
Cautions: ESR may be normal in ~10% of axSpA patients, lowering sensitivity; influenced by comorbidities that raise ESR; not recommended as a strict treat‑to‑target metric in guidelines 3 [Level I evidence].