The ASDAS‑ESR is a composite index that quantifies axial spondyloarthritis activity by combining patient‑reported symptoms with the erythrocyte sedimentation rate.

适用指征

Used to quantify disease activity in axial spondyloarthritis, guide treatment escalation, and classify inactive, low, high, or very high disease activity based on validated cut‑offs (≤1.3, >1.3–2.1, >2.1–3.5, >3.5) 1 [Level I evidence]. Clinically useful for routine monitoring every 3–4 months, as it correlates with radiographic progression 2 [Level II evidence] and reflects both patient symptoms and inflammation more accurately than BASDAI 3 [Level II evidence].

洞见与注意事项

Reflects combined symptoms and ESR to classify activity and track response, correlating well with patient/physician assessments and outperforming BASDAI in discrimination 1 [Level II evidence].
Usefulness includes validated cut‑offs and strong links to MRI and radiographic progression 2 [Level II evidence].
Cautions: ESR may be normal in ~10% of axSpA patients, lowering sensitivity; influenced by comorbidities that raise ESR; not recommended as a strict treat‑to‑target metric in guidelines 3 [Level I evidence].